team photo

Team 5

Team Members

Faculty Advisor

Claire Palin
Ainsley Svetek
Audra McSharry
Tessa Basile
Melissa Lyder

Dr. Guoan Zheng


UConn Biomedical Engineering Department

sponsored by
Sponsor Image Not Available

Antibiotic and Anticancer Drug Screening on a Chip

Our design is a way to image samples in a way that produces a 3D image allowing the researchers to see the sample's depth. This is done through multiple ways. It has a controllable stage that is smoothly translational within x, y and z planes. Two 150mm stepper motors are configured with the stage to allow this movement. Correlating MATLAB code communicates with the stage’s stepper motors through a 3 axis USB controller board in order to move the stage methodically. The stage moves a specified distance at a specified time, to ultimately capture a full image of the cells, based on the MATLAB scripts. One imaging sensor is implemented in our design directly beneath the stage. The sensor ensures a precise image with a specific pixel size of 2.4µm. It does so with a blood coating over its conventional lens that acts as a bio-lens, this design also reduces cost compared to buying a higher quality sensor. The sensor used in conjunction with the blood cells utilizes a 2 X 0.1-NA objective lens and a 4 X 0.2-NA objective lens to create a full field of view of 120mm. The design functions with a glass bottom 35mm petri dish filled with the specified cell and drug assay that requires imaging. A 3-D printed component was designed to hold the petri dish tightly in place during the imaging process, and it rests right above the sensor. A green laser is used for illumination and contrast of the specimen and is secured above the petri dish with a lens slip ring, optical posts, and angle clamps. The base of the device is made of acrylic board, cut to 10in × 8in × 0.47.