Team 23

Team Members

Faculty Advisor

Lauren Dagostino
Allison Fleming
Todor Bliznakov

Patrick Kumavor

Sponsor

Biorasis

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Optimizing Continuous Glucose Monitor (CGM) Performance using Improved Sensor Electrode Design

Biorasis’s goal is to develop a fully implantable device for continuous glucose monitor (CGM) system primarily for Type I diabetic patients. This system continuously monitors the glucose levels assisting in diabetes management by maintaining glycemic levels and preventing acute hypoglycemia and persistent hyperglycemia. The small size of the implant device minimizes trauma due to implantation and removal. The glucose sensing element is composed of platinum working electrode (WE), coated with glucose oxidase enzyme; an Ag/AgCl reference electrode (RE); and platinum counter electrode (CE). The three-electrode system is based on the breakdown of glucose oxidase enzyme, with hydrogen peroxide as the byproduct and current induced when a voltage is applied between the WE and the RE. The sensor current is readout, processed, and then transmitted through an LED to the external proximity communicator. In this project, we optimized the performance of the sensor by investigating sensor electrode design. The tested sensors improved the sensor output current by around 21%. We used microfluidic device as the sensor testing platform.