The objective of this project was to identify the range of forces applied to a syringe containing bleach solution, that would cause the solution to breach the apical foramen during the disinfection stage of a root canal procedure. The apical foramen is a small opening at the root of a tooth where arteries, veins and nerves pass through. If the bleach solution, used to disinfect the canal, breaches the apical foramen, it can result in permanent nerve damage. Two models were used to quantify a range of forces that would cause breaching of the foramen: an experimental model and a mathematical model. The experimental model involved a testing rig designed to enable a repeatable procedure with minimal variability. The rig consisted of a weight loader, syringe holder, force sensor, and data acquisition (DAQ) system. The syringe holder stabilized a 3mL luer lock syringe fitted with a 20-gauge beveled needle, to which a root canal-prepared tooth sample was cemented using dental cement. Known weights were applied to the syringe plunger in 0.5 kg increments to determine whether the bleach solution breached the tooth’s apical foramen, and if so, the applied force at which this occurred. The mathematical model evaluated the syringe, needle, and tooth assembly as a fluid dynamic system. The fluid velocity and pressure at the tooth’s apical foramen were calculated for each applied force to assess whether the bleach solution would breach the apical foramen in a living patient. After measuring the area of each tooth sample’s apical foramen using a confocal laser microscope, with values ranging from 1057.825 μm to 33538.239 μm, the force at which the foramen breached was correlated with the foramen’s cross-sectional area. Both experimental and mathematical results suggested that there is a potential for the bleach solution to breach the apical foramen during the disinfection stage of a root canal procedure.