Our project develops a biomimetic skin fixture to evaluate the adhesive performance of long-term diabetic monitoring patches. Current testing methods rely on non-biological surfaces such as metal plates or styrofoam-like materials, which fail to replicate the mechanical, chemical, and thermal properties of human skin and produce unrealistic adhesion results. Direct testing on human or animal skin is also limited due to ethical concerns. To address this gap, we aim to design a synthetic skin model that mimics key characteristics of human skin, including elasticity, surface texture, moisture, and oil secretion. By integrating clinical research, advanced materials, and mechanical testing standards, this fixture will provide a reproducible and ethical platform for evaluating long-term patch adhesion. This approach will generate more clinically relevant data, improve patch durability and comfort, and support manufacturers in reducing reliance on human testing.