Dr. Thanh Nguyen
UConn Biomedical Engineering Department
This project was aimed to investigate piezoelectric Polylactic Acid (PLLA) as a biomaterial for skin regeneration, which is translational to clinical therapies to treat chronic wounds in burn patients. Piezoelectric PLLA is fabricated as a fibrous scaffold using electrospinning techniques. The scaffold needs to be characterized to determine its suitability to support cell growth and tissue regeneration. The scaffold also needs to demonstrate via its piezoelectric properties enhancement of cell viability and cell adhesion in order to be effective for chronic wound healing applications. For the purpose of facilitating the wound healing process particularly for 3rd-degree burns, newly seeded fibroblasts cells must be capable of surviving on the surface of the scaffold. For the proper formation of the extracellular matrix (ECM) to support the regenerating cells, cells must be able to grow stably on the scaffold.